Clonazepam and Oxycodone: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Clonazepam and Oxycodone unless specifically directed by your doctor.
How Clonazepam interacts with Oxycodone
Clonazepam enhances GABA-A receptor-mediated inhibition, while oxycodone activates mu-opioid receptors. Additive central nervous system and respiratory depression can cause coma or death.
What you should do
Avoid co-prescribing unless alternatives are inadequate. If necessary, use reduced doses for the shortest possible duration, counsel about sedation, and provide close monitoring and naloxone where appropriate.
Key facts
Severity
Major — avoid combination
Mechanism
Clonazepam enhances GABA-A receptor-mediated inhibition, while oxycodone activates mu-opioid receptors. Additive central...
Action
Avoid co-prescribing unless alternatives are inadequate. If necessary, use reduced doses for the shortest possible durat...
Frequently asked questions
Can I take Clonazepam and Oxycodone together?
No — this combination should generally be avoided. Avoid co-prescribing unless alternatives are inadequate. If necessary, use reduced doses for the shortest possible duration, counsel about sedation, and provide close monitoring and naloxone where appropriate.
What is the severity of this interaction?
The interaction between Clonazepam and Oxycodone is classified as Major — avoid combination. Clonazepam enhances GABA-A receptor-mediated inhibition, while oxycodone activates mu-opioid receptors. Additive central nervous system and respiratory depression can cause coma or death.
What should I do if I'm prescribed both?
Avoid co-prescribing unless alternatives are inadequate. If necessary, use reduced doses for the shortest possible duration, counsel about sedation, and provide close monitoring and naloxone where appropriate. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.