Lorazepam and Oxycodone: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Lorazepam and Oxycodone unless specifically directed by your doctor.
How Lorazepam interacts with Oxycodone
Lorazepam enhances GABA-A receptor-mediated inhibition while oxycodone activates mu-opioid receptors, producing additive sedation and respiratory depression.
What you should do
Avoid concurrent prescribing unless alternatives are inadequate. If essential, use the lowest effective doses, limit duration, monitor closely, and provide overdose-risk counseling and naloxone where appropriate.
Key facts
Severity
Major — avoid combination
Mechanism
Lorazepam enhances GABA-A receptor-mediated inhibition while oxycodone activates mu-opioid receptors, producing additive...
Action
Avoid concurrent prescribing unless alternatives are inadequate. If essential, use the lowest effective doses, limit dur...
Frequently asked questions
Can I take Lorazepam and Oxycodone together?
No — this combination should generally be avoided. Avoid concurrent prescribing unless alternatives are inadequate. If essential, use the lowest effective doses, limit duration, monitor closely, and provide overdose-risk counseling and naloxone where appropriate.
What is the severity of this interaction?
The interaction between Lorazepam and Oxycodone is classified as Major — avoid combination. Lorazepam enhances GABA-A receptor-mediated inhibition while oxycodone activates mu-opioid receptors, producing additive sedation and respiratory depression.
What should I do if I'm prescribed both?
Avoid concurrent prescribing unless alternatives are inadequate. If essential, use the lowest effective doses, limit duration, monitor closely, and provide overdose-risk counseling and naloxone where appropriate. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.