Oxycodone and Temazepam: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Oxycodone and Temazepam unless specifically directed by your doctor.
How Oxycodone interacts with Temazepam
Oxycodone activates mu-opioid receptors, while temazepam enhances GABA-A receptor signalling. Additive central nervous system depression can cause profound sedation, respiratory depression, coma, and death.
What you should do
Avoid concurrent prescribing unless alternatives are inadequate. If unavoidable, use the lowest effective doses for the shortest duration, provide overdose education, and consider naloxone.
Key facts
Severity
Major — avoid combination
Mechanism
Oxycodone activates mu-opioid receptors, while temazepam enhances GABA-A receptor signalling. Additive central nervous s...
Action
Avoid concurrent prescribing unless alternatives are inadequate. If unavoidable, use the lowest effective doses for the ...
Frequently asked questions
Can I take Oxycodone and Temazepam together?
No — this combination should generally be avoided. Avoid concurrent prescribing unless alternatives are inadequate. If unavoidable, use the lowest effective doses for the shortest duration, provide overdose education, and consider naloxone.
What is the severity of this interaction?
The interaction between Oxycodone and Temazepam is classified as Major — avoid combination. Oxycodone activates mu-opioid receptors, while temazepam enhances GABA-A receptor signalling. Additive central nervous system depression can cause profound sedation, respiratory depression, coma, and death.
What should I do if I'm prescribed both?
Avoid concurrent prescribing unless alternatives are inadequate. If unavoidable, use the lowest effective doses for the shortest duration, provide overdose education, and consider naloxone. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.