Oxycodone and Zopiclone: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Oxycodone and Zopiclone unless specifically directed by your doctor.
How Oxycodone interacts with Zopiclone
Both drugs depress central nervous system activity through GABAergic and opioid receptor pathways, causing additive sedation and respiratory depression.
What you should do
Avoid routine co-prescribing; if unavoidable, use the lowest effective doses for the shortest duration and counsel about sedation, driving, alcohol, and overdose risk.
Key facts
Severity
Major — avoid combination
Mechanism
Both drugs depress central nervous system activity through GABAergic and opioid receptor pathways, causing additive seda...
Action
Avoid routine co-prescribing; if unavoidable, use the lowest effective doses for the shortest duration and counsel about...
Frequently asked questions
Can I take Oxycodone and Zopiclone together?
No — this combination should generally be avoided. Avoid routine co-prescribing; if unavoidable, use the lowest effective doses for the shortest duration and counsel about sedation, driving, alcohol, and overdose risk.
What is the severity of this interaction?
The interaction between Oxycodone and Zopiclone is classified as Major — avoid combination. Both drugs depress central nervous system activity through GABAergic and opioid receptor pathways, causing additive sedation and respiratory depression.
What should I do if I'm prescribed both?
Avoid routine co-prescribing; if unavoidable, use the lowest effective doses for the shortest duration and counsel about sedation, driving, alcohol, and overdose risk. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.