Clarithromycin and Venetoclax: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Clarithromycin and Venetoclax unless specifically directed by your doctor.
How Clarithromycin interacts with Venetoclax
Clarithromycin strongly inhibits CYP3A4 and P-glycoprotein, markedly increasing venetoclax exposure and the risk of severe toxicity and tumor lysis syndrome.
What you should do
Avoid clarithromycin, particularly during venetoclax initiation and dose ramp-up. If no alternative exists outside ramp-up, apply the mandated venetoclax dose reduction and monitor closely.
Key facts
Severity
Major — avoid combination
Mechanism
Clarithromycin strongly inhibits CYP3A4 and P-glycoprotein, markedly increasing venetoclax exposure and the risk of seve...
Action
Avoid clarithromycin, particularly during venetoclax initiation and dose ramp-up. If no alternative exists outside ramp-...
Frequently asked questions
Can I take Clarithromycin and Venetoclax together?
No — this combination should generally be avoided. Avoid clarithromycin, particularly during venetoclax initiation and dose ramp-up. If no alternative exists outside ramp-up, apply the mandated venetoclax dose reduction and monitor closely.
What is the severity of this interaction?
The interaction between Clarithromycin and Venetoclax is classified as Major — avoid combination. Clarithromycin strongly inhibits CYP3A4 and P-glycoprotein, markedly increasing venetoclax exposure and the risk of severe toxicity and tumor lysis syndrome.
What should I do if I'm prescribed both?
Avoid clarithromycin, particularly during venetoclax initiation and dose ramp-up. If no alternative exists outside ramp-up, apply the mandated venetoclax dose reduction and monitor closely. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.