Ketoconazole and Venetoclax: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Ketoconazole and Venetoclax unless specifically directed by your doctor.
How Ketoconazole interacts with Venetoclax
Ketoconazole strongly inhibits CYP3A4 and P-glycoprotein, markedly increasing venetoclax exposure and the risk of severe toxicity and tumour lysis syndrome.
What you should do
Avoid the combination, particularly during venetoclax initiation and dose escalation. If unavoidable during stable therapy, follow the specified venetoclax dose-reduction protocol.
Key facts
Severity
Major — avoid combination
Mechanism
Ketoconazole strongly inhibits CYP3A4 and P-glycoprotein, markedly increasing venetoclax exposure and the risk of severe...
Action
Avoid the combination, particularly during venetoclax initiation and dose escalation. If unavoidable during stable thera...
Frequently asked questions
Can I take Ketoconazole and Venetoclax together?
No — this combination should generally be avoided. Avoid the combination, particularly during venetoclax initiation and dose escalation. If unavoidable during stable therapy, follow the specified venetoclax dose-reduction protocol.
What is the severity of this interaction?
The interaction between Ketoconazole and Venetoclax is classified as Major — avoid combination. Ketoconazole strongly inhibits CYP3A4 and P-glycoprotein, markedly increasing venetoclax exposure and the risk of severe toxicity and tumour lysis syndrome.
What should I do if I'm prescribed both?
Avoid the combination, particularly during venetoclax initiation and dose escalation. If unavoidable during stable therapy, follow the specified venetoclax dose-reduction protocol. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.