Itraconazole and Venetoclax: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Itraconazole and Venetoclax unless specifically directed by your doctor.
How Itraconazole interacts with Venetoclax
Itraconazole strongly inhibits CYP3A4 and P-glycoprotein, increasing venetoclax exposure. This increases the risk of tumor lysis syndrome and serious hematologic toxicity.
What you should do
Avoid during venetoclax initiation and ramp-up unless specialist protocols specify dose adjustment; use strict tumor lysis monitoring if unavoidable.
Key facts
Severity
Major — avoid combination
Mechanism
Itraconazole strongly inhibits CYP3A4 and P-glycoprotein, increasing venetoclax exposure. This increases the risk of tum...
Action
Avoid during venetoclax initiation and ramp-up unless specialist protocols specify dose adjustment; use strict tumor lys...
Frequently asked questions
Can I take Itraconazole and Venetoclax together?
No — this combination should generally be avoided. Avoid during venetoclax initiation and ramp-up unless specialist protocols specify dose adjustment; use strict tumor lysis monitoring if unavoidable.
What is the severity of this interaction?
The interaction between Itraconazole and Venetoclax is classified as Major — avoid combination. Itraconazole strongly inhibits CYP3A4 and P-glycoprotein, increasing venetoclax exposure. This increases the risk of tumor lysis syndrome and serious hematologic toxicity.
What should I do if I'm prescribed both?
Avoid during venetoclax initiation and ramp-up unless specialist protocols specify dose adjustment; use strict tumor lysis monitoring if unavoidable. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.