Quinidine and Venetoclax: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Quinidine and Venetoclax unless specifically directed by your doctor.
How Quinidine interacts with Venetoclax
Quinidine inhibits P-glycoprotein and can inhibit CYP3A pathways relevant to venetoclax disposition. Increased venetoclax exposure raises the risk of severe neutropenia and tumor lysis syndrome.
What you should do
Avoid strong transporter or CYP3A inhibitors during venetoclax initiation and ramp-up when possible. If unavoidable, follow label-based venetoclax dose reduction and monitoring.
Key facts
Severity
Major — avoid combination
Mechanism
Quinidine inhibits P-glycoprotein and can inhibit CYP3A pathways relevant to venetoclax disposition. Increased venetocla...
Action
Avoid strong transporter or CYP3A inhibitors during venetoclax initiation and ramp-up when possible. If unavoidable, fol...
Frequently asked questions
Can I take Quinidine and Venetoclax together?
No — this combination should generally be avoided. Avoid strong transporter or CYP3A inhibitors during venetoclax initiation and ramp-up when possible. If unavoidable, follow label-based venetoclax dose reduction and monitoring.
What is the severity of this interaction?
The interaction between Quinidine and Venetoclax is classified as Major — avoid combination. Quinidine inhibits P-glycoprotein and can inhibit CYP3A pathways relevant to venetoclax disposition. Increased venetoclax exposure raises the risk of severe neutropenia and tumor lysis syndrome.
What should I do if I'm prescribed both?
Avoid strong transporter or CYP3A inhibitors during venetoclax initiation and ramp-up when possible. If unavoidable, follow label-based venetoclax dose reduction and monitoring. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.