Citalopram and Hydroxyzine: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Citalopram and Hydroxyzine unless specifically directed by your doctor.
How Citalopram interacts with Hydroxyzine
Both drugs inhibit cardiac potassium currents and prolong the QT interval, creating an additive risk of torsades de pointes.
What you should do
Avoid the combination, particularly in patients with cardiac disease, electrolyte abnormalities, or other QT-prolonging therapy. Choose a non-QT-prolonging alternative.
Key facts
Severity
Major — avoid combination
Mechanism
Both drugs inhibit cardiac potassium currents and prolong the QT interval, creating an additive risk of torsades de poin...
Action
Avoid the combination, particularly in patients with cardiac disease, electrolyte abnormalities, or other QT-prolonging ...
Frequently asked questions
Can I take Citalopram and Hydroxyzine together?
No — this combination should generally be avoided. Avoid the combination, particularly in patients with cardiac disease, electrolyte abnormalities, or other QT-prolonging therapy. Choose a non-QT-prolonging alternative.
What is the severity of this interaction?
The interaction between Citalopram and Hydroxyzine is classified as Major — avoid combination. Both drugs inhibit cardiac potassium currents and prolong the QT interval, creating an additive risk of torsades de pointes.
What should I do if I'm prescribed both?
Avoid the combination, particularly in patients with cardiac disease, electrolyte abnormalities, or other QT-prolonging therapy. Choose a non-QT-prolonging alternative. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.