Escitalopram and Hydroxyzine: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Escitalopram and Hydroxyzine unless specifically directed by your doctor.
How Escitalopram interacts with Hydroxyzine
Both drugs inhibit cardiac repolarizing potassium currents and can produce additive QT-interval prolongation and torsades de pointes.
What you should do
Avoid the combination, especially in patients with cardiac disease, electrolyte abnormalities, bradycardia, or other QT-prolonging therapy.
Key facts
Severity
Major — avoid combination
Mechanism
Both drugs inhibit cardiac repolarizing potassium currents and can produce additive QT-interval prolongation and torsade...
Action
Avoid the combination, especially in patients with cardiac disease, electrolyte abnormalities, bradycardia, or other QT-...
Frequently asked questions
Can I take Escitalopram and Hydroxyzine together?
No — this combination should generally be avoided. Avoid the combination, especially in patients with cardiac disease, electrolyte abnormalities, bradycardia, or other QT-prolonging therapy.
What is the severity of this interaction?
The interaction between Escitalopram and Hydroxyzine is classified as Major — avoid combination. Both drugs inhibit cardiac repolarizing potassium currents and can produce additive QT-interval prolongation and torsades de pointes.
What should I do if I'm prescribed both?
Avoid the combination, especially in patients with cardiac disease, electrolyte abnormalities, bradycardia, or other QT-prolonging therapy. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.