Hydroxyzine and Sotalol: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Hydroxyzine and Sotalol unless specifically directed by your doctor.
How Hydroxyzine interacts with Sotalol
Both drugs can prolong cardiac repolarization through effects on potassium currents, increasing QT interval. Combined use raises the risk of torsades de pointes.
What you should do
Avoid the combination when possible; choose a non-QT-prolonging alternative and correct electrolyte abnormalities.
Key facts
Severity
Major — avoid combination
Mechanism
Both drugs can prolong cardiac repolarization through effects on potassium currents, increasing QT interval. Combined us...
Action
Avoid the combination when possible; choose a non-QT-prolonging alternative and correct electrolyte abnormalities.
Frequently asked questions
Can I take Hydroxyzine and Sotalol together?
No — this combination should generally be avoided. Avoid the combination when possible; choose a non-QT-prolonging alternative and correct electrolyte abnormalities.
What is the severity of this interaction?
The interaction between Hydroxyzine and Sotalol is classified as Major — avoid combination. Both drugs can prolong cardiac repolarization through effects on potassium currents, increasing QT interval. Combined use raises the risk of torsades de pointes.
What should I do if I'm prescribed both?
Avoid the combination when possible; choose a non-QT-prolonging alternative and correct electrolyte abnormalities. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.