Citalopram and Pimozide: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Citalopram and Pimozide unless specifically directed by your doctor.
How Citalopram interacts with Pimozide
Both drugs inhibit cardiac repolarizing potassium currents and prolong the QT interval, creating a substantial pharmacodynamic risk of torsades de pointes.
What you should do
Do not co-prescribe this contraindicated combination. Select an alternative antidepressant or antipsychotic with lower QT liability.
Key facts
Severity
Major — avoid combination
Mechanism
Both drugs inhibit cardiac repolarizing potassium currents and prolong the QT interval, creating a substantial pharmacod...
Action
Do not co-prescribe this contraindicated combination. Select an alternative antidepressant or antipsychotic with lower Q...
Frequently asked questions
Can I take Citalopram and Pimozide together?
No — this combination should generally be avoided. Do not co-prescribe this contraindicated combination. Select an alternative antidepressant or antipsychotic with lower QT liability.
What is the severity of this interaction?
The interaction between Citalopram and Pimozide is classified as Major — avoid combination. Both drugs inhibit cardiac repolarizing potassium currents and prolong the QT interval, creating a substantial pharmacodynamic risk of torsades de pointes.
What should I do if I'm prescribed both?
Do not co-prescribe this contraindicated combination. Select an alternative antidepressant or antipsychotic with lower QT liability. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.