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Ciprofloxacin and Theophylline: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Ciprofloxacin and Theophylline unless specifically directed by your doctor.

Interaction severity: Major — avoid combination

How Ciprofloxacin interacts with Theophylline

Ciprofloxacin inhibits CYP1A2-mediated metabolism of theophylline, raising serum levels and increasing risk of seizures and cardiac arrhythmias.

What you should do

Avoid concurrent use if possible. If required, reduce theophylline dose by 30-50% and monitor serum theophylline levels.

Key facts

Severity

Major — avoid combination

Mechanism

Ciprofloxacin inhibits CYP1A2-mediated metabolism of theophylline, raising serum levels and increasing risk of seizures ...

Action

Avoid concurrent use if possible. If required, reduce theophylline dose by 30-50% and monitor serum theophylline levels.

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Ciprofloxacin and Theophylline together?

No — this combination should generally be avoided. Avoid concurrent use if possible. If required, reduce theophylline dose by 30-50% and monitor serum theophylline levels.

What is the severity of this interaction?

The interaction between Ciprofloxacin and Theophylline is classified as Major — avoid combination. Ciprofloxacin inhibits CYP1A2-mediated metabolism of theophylline, raising serum levels and increasing risk of seizures and cardiac arrhythmias.

What should I do if I'm prescribed both?

Avoid concurrent use if possible. If required, reduce theophylline dose by 30-50% and monitor serum theophylline levels. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.