Warfarin and Ibuprofen: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Warfarin and Ibuprofen unless specifically directed by your doctor.
How Warfarin interacts with Ibuprofen
Ibuprofen increases bleeding risk in patients on warfarin via platelet inhibition and gastric mucosal damage.
What you should do
Avoid this combination. Use paracetamol (acetaminophen) for pain instead.
Key facts
Severity
Major — avoid combination
Mechanism
Ibuprofen increases bleeding risk in patients on warfarin via platelet inhibition and gastric mucosal damage.
Action
Avoid this combination. Use paracetamol (acetaminophen) for pain instead.
Frequently asked questions
Can I take Warfarin and Ibuprofen together?
No — this combination should generally be avoided. Avoid this combination. Use paracetamol (acetaminophen) for pain instead.
What is the severity of this interaction?
The interaction between Warfarin and Ibuprofen is classified as Major — avoid combination. Ibuprofen increases bleeding risk in patients on warfarin via platelet inhibition and gastric mucosal damage.
What should I do if I'm prescribed both?
Avoid this combination. Use paracetamol (acetaminophen) for pain instead. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.