Fluvoxamine and Theophylline: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Fluvoxamine and Theophylline unless specifically directed by your doctor.
How Fluvoxamine interacts with Theophylline
Fluvoxamine potently inhibits CYP1A2, the principal enzyme metabolizing theophylline, producing up to 3-fold increases in theophylline levels and risk of seizures and arrhythmia.
What you should do
Reduce theophylline dose to one-third when starting fluvoxamine and monitor theophylline levels closely; prefer alternative SSRI.
Key facts
Severity
Major — avoid combination
Mechanism
Fluvoxamine potently inhibits CYP1A2, the principal enzyme metabolizing theophylline, producing up to 3-fold increases i...
Action
Reduce theophylline dose to one-third when starting fluvoxamine and monitor theophylline levels closely; prefer alternat...
Frequently asked questions
Can I take Fluvoxamine and Theophylline together?
No — this combination should generally be avoided. Reduce theophylline dose to one-third when starting fluvoxamine and monitor theophylline levels closely; prefer alternative SSRI.
What is the severity of this interaction?
The interaction between Fluvoxamine and Theophylline is classified as Major — avoid combination. Fluvoxamine potently inhibits CYP1A2, the principal enzyme metabolizing theophylline, producing up to 3-fold increases in theophylline levels and risk of seizures and arrhythmia.
What should I do if I'm prescribed both?
Reduce theophylline dose to one-third when starting fluvoxamine and monitor theophylline levels closely; prefer alternative SSRI. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.