Ciprofloxacin and Tizanidine: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Ciprofloxacin and Tizanidine unless specifically directed by your doctor.
How Ciprofloxacin interacts with Tizanidine
Ciprofloxacin is a potent CYP1A2 inhibitor, blocking metabolism of tizanidine and producing up to 10-fold increases in plasma concentrations with profound hypotension and sedation.
What you should do
Combination is contraindicated; choose an alternative antibiotic (e.g., amoxicillin, doxycycline) or alternative muscle relaxant.
Key facts
Severity
Major — avoid combination
Mechanism
Ciprofloxacin is a potent CYP1A2 inhibitor, blocking metabolism of tizanidine and producing up to 10-fold increases in p...
Action
Combination is contraindicated; choose an alternative antibiotic (e.g., amoxicillin, doxycycline) or alternative muscle ...
Frequently asked questions
Can I take Ciprofloxacin and Tizanidine together?
No — this combination should generally be avoided. Combination is contraindicated; choose an alternative antibiotic (e.g., amoxicillin, doxycycline) or alternative muscle relaxant.
What is the severity of this interaction?
The interaction between Ciprofloxacin and Tizanidine is classified as Major — avoid combination. Ciprofloxacin is a potent CYP1A2 inhibitor, blocking metabolism of tizanidine and producing up to 10-fold increases in plasma concentrations with profound hypotension and sedation.
What should I do if I'm prescribed both?
Combination is contraindicated; choose an alternative antibiotic (e.g., amoxicillin, doxycycline) or alternative muscle relaxant. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.