Carbamazepine and Levonorgestrel: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Carbamazepine and Levonorgestrel unless specifically directed by your doctor.
How Carbamazepine interacts with Levonorgestrel
Carbamazepine induces CYP3A4 and other drug-metabolizing enzymes, accelerating levonorgestrel clearance and reducing the effectiveness of oral and implantable contraception.
What you should do
Do not rely on levonorgestrel-based systemic contraception during carbamazepine therapy. Use a contraceptive method unaffected by enzyme induction and follow emergency-contraception guidance when relevant.
Key facts
Severity
Major — avoid combination
Mechanism
Carbamazepine induces CYP3A4 and other drug-metabolizing enzymes, accelerating levonorgestrel clearance and reducing the...
Action
Do not rely on levonorgestrel-based systemic contraception during carbamazepine therapy. Use a contraceptive method unaf...
Frequently asked questions
Can I take Carbamazepine and Levonorgestrel together?
No — this combination should generally be avoided. Do not rely on levonorgestrel-based systemic contraception during carbamazepine therapy. Use a contraceptive method unaffected by enzyme induction and follow emergency-contraception guidance when relevant.
What is the severity of this interaction?
The interaction between Carbamazepine and Levonorgestrel is classified as Major — avoid combination. Carbamazepine induces CYP3A4 and other drug-metabolizing enzymes, accelerating levonorgestrel clearance and reducing the effectiveness of oral and implantable contraception.
What should I do if I'm prescribed both?
Do not rely on levonorgestrel-based systemic contraception during carbamazepine therapy. Use a contraceptive method unaffected by enzyme induction and follow emergency-contraception guidance when relevant. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.