Carbamazepine and Ethinylestradiol Levonorgestrel: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Carbamazepine and Ethinylestradiol Levonorgestrel unless specifically directed by your doctor.
How Carbamazepine interacts with Ethinylestradiol Levonorgestrel
Carbamazepine induces CYP3A4 and glucuronidation pathways, accelerating metabolism of both contraceptive hormones and reducing contraceptive efficacy.
What you should do
Use a contraceptive method unaffected by enzyme induction, such as an intrauterine method. Continue alternative contraception for the recommended period after carbamazepine is stopped.
Key facts
Severity
Major — avoid combination
Mechanism
Carbamazepine induces CYP3A4 and glucuronidation pathways, accelerating metabolism of both contraceptive hormones and re...
Action
Use a contraceptive method unaffected by enzyme induction, such as an intrauterine method. Continue alternative contrace...
Frequently asked questions
Can I take Carbamazepine and Ethinylestradiol Levonorgestrel together?
No — this combination should generally be avoided. Use a contraceptive method unaffected by enzyme induction, such as an intrauterine method. Continue alternative contraception for the recommended period after carbamazepine is stopped.
What is the severity of this interaction?
The interaction between Carbamazepine and Ethinylestradiol Levonorgestrel is classified as Major — avoid combination. Carbamazepine induces CYP3A4 and glucuronidation pathways, accelerating metabolism of both contraceptive hormones and reducing contraceptive efficacy.
What should I do if I'm prescribed both?
Use a contraceptive method unaffected by enzyme induction, such as an intrauterine method. Continue alternative contraception for the recommended period after carbamazepine is stopped. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.