Ethinylestradiol Levonorgestrel and Phenytoin: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Ethinylestradiol Levonorgestrel and Phenytoin unless specifically directed by your doctor.

Interaction severity: Major — avoid combination

How Ethinylestradiol Levonorgestrel interacts with Phenytoin

Phenytoin induces CYP3A4 and glucuronidation pathways, accelerating metabolism of contraceptive hormones and increasing the risk of contraceptive failure.

What you should do

Avoid relying on the combined hormonal contraceptive. Use an effective method unaffected by enzyme induction during treatment and for the recommended interval after phenytoin discontinuation.

Key facts

Severity

Major — avoid combination

Mechanism

Phenytoin induces CYP3A4 and glucuronidation pathways, accelerating metabolism of contraceptive hormones and increasing ...

Action

Avoid relying on the combined hormonal contraceptive. Use an effective method unaffected by enzyme induction during trea...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Ethinylestradiol Levonorgestrel and Phenytoin together?

No — this combination should generally be avoided. Avoid relying on the combined hormonal contraceptive. Use an effective method unaffected by enzyme induction during treatment and for the recommended interval after phenytoin discontinuation.

What is the severity of this interaction?

The interaction between Ethinylestradiol Levonorgestrel and Phenytoin is classified as Major — avoid combination. Phenytoin induces CYP3A4 and glucuronidation pathways, accelerating metabolism of contraceptive hormones and increasing the risk of contraceptive failure.

What should I do if I'm prescribed both?

Avoid relying on the combined hormonal contraceptive. Use an effective method unaffected by enzyme induction during treatment and for the recommended interval after phenytoin discontinuation. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.