Levonorgestrel and Rifampicin: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Levonorgestrel and Rifampicin unless specifically directed by your doctor.

Interaction severity: Major — avoid combination

How Levonorgestrel interacts with Rifampicin

Rifampicin strongly induces CYP3A4 and glucuronidation pathways, accelerating levonorgestrel metabolism and reducing contraceptive efficacy.

What you should do

Use a contraceptive method unaffected by enzyme induction during rifampicin treatment and for the recommended period after its discontinuation.

Key facts

Severity

Major — avoid combination

Mechanism

Rifampicin strongly induces CYP3A4 and glucuronidation pathways, accelerating levonorgestrel metabolism and reducing con...

Action

Use a contraceptive method unaffected by enzyme induction during rifampicin treatment and for the recommended period aft...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Levonorgestrel and Rifampicin together?

No — this combination should generally be avoided. Use a contraceptive method unaffected by enzyme induction during rifampicin treatment and for the recommended period after its discontinuation.

What is the severity of this interaction?

The interaction between Levonorgestrel and Rifampicin is classified as Major — avoid combination. Rifampicin strongly induces CYP3A4 and glucuronidation pathways, accelerating levonorgestrel metabolism and reducing contraceptive efficacy.

What should I do if I'm prescribed both?

Use a contraceptive method unaffected by enzyme induction during rifampicin treatment and for the recommended period after its discontinuation. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.