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Amlodipine and Clarithromycin: Drug Interaction Guide

Quick answer: This combination requires caution. Amlodipine and Clarithromycin can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Amlodipine interacts with Clarithromycin

Clarithromycin inhibits CYP3A4 metabolism of amlodipine, increasing plasma levels and producing clinically significant hypotension, especially in elderly patients.

What you should do

Monitor blood pressure during the clarithromycin course; consider holding or halving the amlodipine dose if symptomatic hypotension develops, or substitute azithromycin.

Key facts

Severity

Moderate — caution required

Mechanism

Clarithromycin inhibits CYP3A4 metabolism of amlodipine, increasing plasma levels and producing clinically significant h...

Action

Monitor blood pressure during the clarithromycin course; consider holding or halving the amlodipine dose if symptomatic ...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Amlodipine and Clarithromycin together?

With caution. Monitor blood pressure during the clarithromycin course; consider holding or halving the amlodipine dose if symptomatic hypotension develops, or substitute azithromycin.

What is the severity of this interaction?

The interaction between Amlodipine and Clarithromycin is classified as Moderate — caution required. Clarithromycin inhibits CYP3A4 metabolism of amlodipine, increasing plasma levels and producing clinically significant hypotension, especially in elderly patients.

What should I do if I'm prescribed both?

Monitor blood pressure during the clarithromycin course; consider holding or halving the amlodipine dose if symptomatic hypotension develops, or substitute azithromycin. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.