Clarithromycin and Oxycodone: Drug Interaction Guide

Quick answer: This combination requires caution. Clarithromycin and Oxycodone can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Clarithromycin interacts with Oxycodone

Clarithromycin inhibits CYP3A4-mediated oxycodone metabolism, increasing opioid exposure and the risk of excessive sedation and respiratory depression.

What you should do

Use an alternative antibiotic or reduce the oxycodone dose. Monitor respiratory rate, consciousness, and opioid adverse effects closely.

Key facts

Severity

Moderate — caution required

Mechanism

Clarithromycin inhibits CYP3A4-mediated oxycodone metabolism, increasing opioid exposure and the risk of excessive sedat...

Action

Use an alternative antibiotic or reduce the oxycodone dose. Monitor respiratory rate, consciousness, and opioid adverse ...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Clarithromycin and Oxycodone together?

With caution. Use an alternative antibiotic or reduce the oxycodone dose. Monitor respiratory rate, consciousness, and opioid adverse effects closely.

What is the severity of this interaction?

The interaction between Clarithromycin and Oxycodone is classified as Moderate — caution required. Clarithromycin inhibits CYP3A4-mediated oxycodone metabolism, increasing opioid exposure and the risk of excessive sedation and respiratory depression.

What should I do if I'm prescribed both?

Use an alternative antibiotic or reduce the oxycodone dose. Monitor respiratory rate, consciousness, and opioid adverse effects closely. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.