Clarithromycin and Rivaroxaban: Drug Interaction Guide

Quick answer: This combination requires caution. Clarithromycin and Rivaroxaban can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Clarithromycin interacts with Rivaroxaban

Clarithromycin inhibits CYP3A4 and P-glycoprotein, both involved in rivaroxaban clearance. Increased rivaroxaban exposure can raise bleeding risk.

What you should do

Use caution, particularly in renal impairment or high bleeding risk. Consider an alternative antibiotic and monitor for bleeding.

Key facts

Severity

Moderate — caution required

Mechanism

Clarithromycin inhibits CYP3A4 and P-glycoprotein, both involved in rivaroxaban clearance. Increased rivaroxaban exposur...

Action

Use caution, particularly in renal impairment or high bleeding risk. Consider an alternative antibiotic and monitor for ...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Clarithromycin and Rivaroxaban together?

With caution. Use caution, particularly in renal impairment or high bleeding risk. Consider an alternative antibiotic and monitor for bleeding.

What is the severity of this interaction?

The interaction between Clarithromycin and Rivaroxaban is classified as Moderate — caution required. Clarithromycin inhibits CYP3A4 and P-glycoprotein, both involved in rivaroxaban clearance. Increased rivaroxaban exposure can raise bleeding risk.

What should I do if I'm prescribed both?

Use caution, particularly in renal impairment or high bleeding risk. Consider an alternative antibiotic and monitor for bleeding. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.