Clarithromycin and Zopiclone: Drug Interaction Guide

Quick answer: This combination requires caution. Clarithromycin and Zopiclone can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Clarithromycin interacts with Zopiclone

Clarithromycin inhibits CYP3A4, reducing zopiclone metabolism and increasing sedative exposure. This can increase next-day sedation, falls, and psychomotor impairment.

What you should do

Use a lower zopiclone dose or avoid temporary co-prescribing. Warn patients not to drive or perform hazardous tasks if sedated.

Key facts

Severity

Moderate — caution required

Mechanism

Clarithromycin inhibits CYP3A4, reducing zopiclone metabolism and increasing sedative exposure. This can increase next-d...

Action

Use a lower zopiclone dose or avoid temporary co-prescribing. Warn patients not to drive or perform hazardous tasks if s...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Clarithromycin and Zopiclone together?

With caution. Use a lower zopiclone dose or avoid temporary co-prescribing. Warn patients not to drive or perform hazardous tasks if sedated.

What is the severity of this interaction?

The interaction between Clarithromycin and Zopiclone is classified as Moderate — caution required. Clarithromycin inhibits CYP3A4, reducing zopiclone metabolism and increasing sedative exposure. This can increase next-day sedation, falls, and psychomotor impairment.

What should I do if I'm prescribed both?

Use a lower zopiclone dose or avoid temporary co-prescribing. Warn patients not to drive or perform hazardous tasks if sedated. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.