Amiodarone and Flecainide: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Amiodarone and Flecainide unless specifically directed by your doctor.
How Amiodarone interacts with Flecainide
Amiodarone inhibits CYP2D6 and CYP3A4, raising flecainide concentrations; both drugs depress conduction with additive proarrhythmic and negative inotropic effects.
What you should do
Reduce flecainide dose by 30-50% and monitor ECG (QRS widening) and clinical status; avoid in patients with structural heart disease.
Key facts
Severity
Major — avoid combination
Mechanism
Amiodarone inhibits CYP2D6 and CYP3A4, raising flecainide concentrations; both drugs depress conduction with additive pr...
Action
Reduce flecainide dose by 30-50% and monitor ECG (QRS widening) and clinical status; avoid in patients with structural h...
Frequently asked questions
Can I take Amiodarone and Flecainide together?
No — this combination should generally be avoided. Reduce flecainide dose by 30-50% and monitor ECG (QRS widening) and clinical status; avoid in patients with structural heart disease.
What is the severity of this interaction?
The interaction between Amiodarone and Flecainide is classified as Major — avoid combination. Amiodarone inhibits CYP2D6 and CYP3A4, raising flecainide concentrations; both drugs depress conduction with additive proarrhythmic and negative inotropic effects.
What should I do if I'm prescribed both?
Reduce flecainide dose by 30-50% and monitor ECG (QRS widening) and clinical status; avoid in patients with structural heart disease. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.