Digoxin and Amiodarone: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Digoxin and Amiodarone unless specifically directed by your doctor.
How Digoxin interacts with Amiodarone
Amiodarone doubles digoxin levels via P-glycoprotein inhibition.
What you should do
Reduce digoxin dose by 50% and monitor digoxin levels closely.
Key facts
Severity
Major — avoid combination
Mechanism
Amiodarone doubles digoxin levels via P-glycoprotein inhibition.
Action
Reduce digoxin dose by 50% and monitor digoxin levels closely.
Frequently asked questions
Can I take Digoxin and Amiodarone together?
No — this combination should generally be avoided. Reduce digoxin dose by 50% and monitor digoxin levels closely.
What is the severity of this interaction?
The interaction between Digoxin and Amiodarone is classified as Major — avoid combination. Amiodarone doubles digoxin levels via P-glycoprotein inhibition.
What should I do if I'm prescribed both?
Reduce digoxin dose by 50% and monitor digoxin levels closely. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.