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Amiodarone and Warfarin: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Amiodarone and Warfarin unless specifically directed by your doctor.

Interaction severity: Major — avoid combination

How Amiodarone interacts with Warfarin

Amiodarone raises warfarin INR by 30-50% within 1-2 weeks.

What you should do

Reduce warfarin dose 30% on amiodarone start; monitor INR weekly for 4 weeks.

Key facts

Severity

Major — avoid combination

Mechanism

Amiodarone raises warfarin INR by 30-50% within 1-2 weeks.

Action

Reduce warfarin dose 30% on amiodarone start; monitor INR weekly for 4 weeks.

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Amiodarone and Warfarin together?

No — this combination should generally be avoided. Reduce warfarin dose 30% on amiodarone start; monitor INR weekly for 4 weeks.

What is the severity of this interaction?

The interaction between Amiodarone and Warfarin is classified as Major — avoid combination. Amiodarone raises warfarin INR by 30-50% within 1-2 weeks.

What should I do if I'm prescribed both?

Reduce warfarin dose 30% on amiodarone start; monitor INR weekly for 4 weeks. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.