Amiodarone and Simvastatin: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Amiodarone and Simvastatin unless specifically directed by your doctor.
How Amiodarone interacts with Simvastatin
Amiodarone inhibits CYP3A4 metabolism of simvastatin, increasing systemic exposure and the risk of myopathy and rhabdomyolysis.
What you should do
Limit simvastatin dose to 20 mg/day when co-administered with amiodarone, or switch to pravastatin or rosuvastatin.
Key facts
Severity
Major — avoid combination
Mechanism
Amiodarone inhibits CYP3A4 metabolism of simvastatin, increasing systemic exposure and the risk of myopathy and rhabdomy...
Action
Limit simvastatin dose to 20 mg/day when co-administered with amiodarone, or switch to pravastatin or rosuvastatin.
Frequently asked questions
Can I take Amiodarone and Simvastatin together?
No — this combination should generally be avoided. Limit simvastatin dose to 20 mg/day when co-administered with amiodarone, or switch to pravastatin or rosuvastatin.
What is the severity of this interaction?
The interaction between Amiodarone and Simvastatin is classified as Major — avoid combination. Amiodarone inhibits CYP3A4 metabolism of simvastatin, increasing systemic exposure and the risk of myopathy and rhabdomyolysis.
What should I do if I'm prescribed both?
Limit simvastatin dose to 20 mg/day when co-administered with amiodarone, or switch to pravastatin or rosuvastatin. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.