Aliskiren and Ramipril: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Aliskiren and Ramipril unless specifically directed by your doctor.
How Aliskiren interacts with Ramipril
Combined renin inhibition and angiotensin-converting enzyme inhibition produce excessive renin-angiotensin-aldosterone system blockade, increasing hyperkalaemia, hypotension, and renal impairment.
What you should do
Avoid combined use, particularly in patients with diabetes or renal impairment. Select a single renin-angiotensin system inhibitor.
Key facts
Severity
Major — avoid combination
Mechanism
Combined renin inhibition and angiotensin-converting enzyme inhibition produce excessive renin-angiotensin-aldosterone s...
Action
Avoid combined use, particularly in patients with diabetes or renal impairment. Select a single renin-angiotensin system...
Frequently asked questions
Can I take Aliskiren and Ramipril together?
No — this combination should generally be avoided. Avoid combined use, particularly in patients with diabetes or renal impairment. Select a single renin-angiotensin system inhibitor.
What is the severity of this interaction?
The interaction between Aliskiren and Ramipril is classified as Major — avoid combination. Combined renin inhibition and angiotensin-converting enzyme inhibition produce excessive renin-angiotensin-aldosterone system blockade, increasing hyperkalaemia, hypotension, and renal impairment.
What should I do if I'm prescribed both?
Avoid combined use, particularly in patients with diabetes or renal impairment. Select a single renin-angiotensin system inhibitor. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.