Aliskiren and Losartan: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Aliskiren and Losartan unless specifically directed by your doctor.
How Aliskiren interacts with Losartan
Dual renin-angiotensin system blockade increases the risk of hyperkalemia, hypotension, and acute kidney injury through additive suppression of angiotensin II and aldosterone.
What you should do
Avoid this combination, especially in diabetes or renal impairment. If exceptional use is considered, monitor potassium, creatinine, and blood pressure closely.
Key facts
Severity
Major — avoid combination
Mechanism
Dual renin-angiotensin system blockade increases the risk of hyperkalemia, hypotension, and acute kidney injury through ...
Action
Avoid this combination, especially in diabetes or renal impairment. If exceptional use is considered, monitor potassium,...
Frequently asked questions
Can I take Aliskiren and Losartan together?
No — this combination should generally be avoided. Avoid this combination, especially in diabetes or renal impairment. If exceptional use is considered, monitor potassium, creatinine, and blood pressure closely.
What is the severity of this interaction?
The interaction between Aliskiren and Losartan is classified as Major — avoid combination. Dual renin-angiotensin system blockade increases the risk of hyperkalemia, hypotension, and acute kidney injury through additive suppression of angiotensin II and aldosterone.
What should I do if I'm prescribed both?
Avoid this combination, especially in diabetes or renal impairment. If exceptional use is considered, monitor potassium, creatinine, and blood pressure closely. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.