Ramipril and Sacubitril: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Ramipril and Sacubitril unless specifically directed by your doctor.
How Ramipril interacts with Sacubitril
ACE inhibitors increase bradykinin, and sacubitril inhibits neprilysin-mediated bradykinin degradation. Combined or closely sequential use increases angioedema risk.
What you should do
Do not coadminister. Allow an appropriate washout interval after stopping an ACE inhibitor before starting sacubitril-valsartan.
Key facts
Severity
Major — avoid combination
Mechanism
ACE inhibitors increase bradykinin, and sacubitril inhibits neprilysin-mediated bradykinin degradation. Combined or clos...
Action
Do not coadminister. Allow an appropriate washout interval after stopping an ACE inhibitor before starting sacubitril-va...
Frequently asked questions
Can I take Ramipril and Sacubitril together?
No — this combination should generally be avoided. Do not coadminister. Allow an appropriate washout interval after stopping an ACE inhibitor before starting sacubitril-valsartan.
What is the severity of this interaction?
The interaction between Ramipril and Sacubitril is classified as Major — avoid combination. ACE inhibitors increase bradykinin, and sacubitril inhibits neprilysin-mediated bradykinin degradation. Combined or closely sequential use increases angioedema risk.
What should I do if I'm prescribed both?
Do not coadminister. Allow an appropriate washout interval after stopping an ACE inhibitor before starting sacubitril-valsartan. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.