Losartan and Ramipril: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Losartan and Ramipril unless specifically directed by your doctor.

Interaction severity: Major — avoid combination

How Losartan interacts with Ramipril

Combined angiotensin-receptor blockade and angiotensin-converting-enzyme inhibition excessively suppress the renin-angiotensin-aldosterone system, increasing hyperkalaemia, hypotension, and acute kidney injury.

What you should do

Avoid routine dual renin-angiotensin system blockade. Use one agent and monitor renal function, potassium, and blood pressure.

Key facts

Severity

Major — avoid combination

Mechanism

Combined angiotensin-receptor blockade and angiotensin-converting-enzyme inhibition excessively suppress the renin-angio...

Action

Avoid routine dual renin-angiotensin system blockade. Use one agent and monitor renal function, potassium, and blood pre...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Losartan and Ramipril together?

No — this combination should generally be avoided. Avoid routine dual renin-angiotensin system blockade. Use one agent and monitor renal function, potassium, and blood pressure.

What is the severity of this interaction?

The interaction between Losartan and Ramipril is classified as Major — avoid combination. Combined angiotensin-receptor blockade and angiotensin-converting-enzyme inhibition excessively suppress the renin-angiotensin-aldosterone system, increasing hyperkalaemia, hypotension, and acute kidney injury.

What should I do if I'm prescribed both?

Avoid routine dual renin-angiotensin system blockade. Use one agent and monitor renal function, potassium, and blood pressure. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.