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Ssri and Maoi: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Ssri and Maoi unless specifically directed by your doctor.

Interaction severity: Major — avoid combination

How Ssri interacts with Maoi

Risk of fatal serotonin syndrome.

What you should do

Absolute contraindication. Wait 14 days between switching.

Key facts

Severity

Major — avoid combination

Mechanism

Risk of fatal serotonin syndrome.

Action

Absolute contraindication. Wait 14 days between switching.

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Ssri and Maoi together?

No — this combination should generally be avoided. Absolute contraindication. Wait 14 days between switching.

What is the severity of this interaction?

The interaction between Ssri and Maoi is classified as Major — avoid combination. Risk of fatal serotonin syndrome.

What should I do if I'm prescribed both?

Absolute contraindication. Wait 14 days between switching. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.