Ssri and Tramadol: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Ssri and Tramadol unless specifically directed by your doctor.
How Ssri interacts with Tramadol
Both increase serotonin — risk of serotonin syndrome (agitation, hyperthermia, rigidity).
What you should do
Avoid combination. Use alternative analgesic (paracetamol, NSAID if appropriate).
Key facts
Severity
Major — avoid combination
Mechanism
Both increase serotonin — risk of serotonin syndrome (agitation, hyperthermia, rigidity).
Action
Avoid combination. Use alternative analgesic (paracetamol, NSAID if appropriate).
Frequently asked questions
Can I take Ssri and Tramadol together?
No — this combination should generally be avoided. Avoid combination. Use alternative analgesic (paracetamol, NSAID if appropriate).
What is the severity of this interaction?
The interaction between Ssri and Tramadol is classified as Major — avoid combination. Both increase serotonin — risk of serotonin syndrome (agitation, hyperthermia, rigidity).
What should I do if I'm prescribed both?
Avoid combination. Use alternative analgesic (paracetamol, NSAID if appropriate). Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.