Rosuvastatin and Transplant Cyclosporine: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Rosuvastatin and Transplant Cyclosporine unless specifically directed by your doctor.
How Rosuvastatin interacts with Transplant Cyclosporine
Cyclosporine inhibits OATP1B1, OATP1B3, BCRP, and other transport pathways, substantially increasing rosuvastatin exposure and myopathy risk.
What you should do
Avoid the combination where required by local product guidance or restrict rosuvastatin to the recommended low maximum dose. Monitor for muscle symptoms and creatine kinase elevation.
Key facts
Severity
Major — avoid combination
Mechanism
Cyclosporine inhibits OATP1B1, OATP1B3, BCRP, and other transport pathways, substantially increasing rosuvastatin exposu...
Action
Avoid the combination where required by local product guidance or restrict rosuvastatin to the recommended low maximum d...
Frequently asked questions
Can I take Rosuvastatin and Transplant Cyclosporine together?
No — this combination should generally be avoided. Avoid the combination where required by local product guidance or restrict rosuvastatin to the recommended low maximum dose. Monitor for muscle symptoms and creatine kinase elevation.
What is the severity of this interaction?
The interaction between Rosuvastatin and Transplant Cyclosporine is classified as Major — avoid combination. Cyclosporine inhibits OATP1B1, OATP1B3, BCRP, and other transport pathways, substantially increasing rosuvastatin exposure and myopathy risk.
What should I do if I'm prescribed both?
Avoid the combination where required by local product guidance or restrict rosuvastatin to the recommended low maximum dose. Monitor for muscle symptoms and creatine kinase elevation. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.