Cyclosporine and Rosuvastatin: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Cyclosporine and Rosuvastatin unless specifically directed by your doctor.
How Cyclosporine interacts with Rosuvastatin
Cyclosporine inhibits OATP1B1 and BCRP transporters, increasing rosuvastatin AUC up to 7-fold with markedly increased myopathy risk.
What you should do
Limit rosuvastatin to a maximum of 5 mg daily in patients on cyclosporine and monitor creatine kinase and symptoms of myopathy.
Key facts
Severity
Major — avoid combination
Mechanism
Cyclosporine inhibits OATP1B1 and BCRP transporters, increasing rosuvastatin AUC up to 7-fold with markedly increased my...
Action
Limit rosuvastatin to a maximum of 5 mg daily in patients on cyclosporine and monitor creatine kinase and symptoms of my...
Frequently asked questions
Can I take Cyclosporine and Rosuvastatin together?
No — this combination should generally be avoided. Limit rosuvastatin to a maximum of 5 mg daily in patients on cyclosporine and monitor creatine kinase and symptoms of myopathy.
What is the severity of this interaction?
The interaction between Cyclosporine and Rosuvastatin is classified as Major — avoid combination. Cyclosporine inhibits OATP1B1 and BCRP transporters, increasing rosuvastatin AUC up to 7-fold with markedly increased myopathy risk.
What should I do if I'm prescribed both?
Limit rosuvastatin to a maximum of 5 mg daily in patients on cyclosporine and monitor creatine kinase and symptoms of myopathy. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.