Cyclosporine and Tacrolimus: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Cyclosporine and Tacrolimus unless specifically directed by your doctor.
How Cyclosporine interacts with Tacrolimus
Both calcineurin inhibitors cause dose-related nephrotoxicity, neurotoxicity, immunosuppression, and electrolyte disturbances, resulting in substantial additive toxicity.
What you should do
Do not administer concurrently; when switching agents, allow an appropriate interval and monitor renal function and drug concentrations.
Key facts
Severity
Major — avoid combination
Mechanism
Both calcineurin inhibitors cause dose-related nephrotoxicity, neurotoxicity, immunosuppression, and electrolyte disturb...
Action
Do not administer concurrently; when switching agents, allow an appropriate interval and monitor renal function and drug...
Frequently asked questions
Can I take Cyclosporine and Tacrolimus together?
No — this combination should generally be avoided. Do not administer concurrently; when switching agents, allow an appropriate interval and monitor renal function and drug concentrations.
What is the severity of this interaction?
The interaction between Cyclosporine and Tacrolimus is classified as Major — avoid combination. Both calcineurin inhibitors cause dose-related nephrotoxicity, neurotoxicity, immunosuppression, and electrolyte disturbances, resulting in substantial additive toxicity.
What should I do if I'm prescribed both?
Do not administer concurrently; when switching agents, allow an appropriate interval and monitor renal function and drug concentrations. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.