Sacubitril Valsartan and Valsartan: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Sacubitril Valsartan and Valsartan unless specifically directed by your doctor.

Interaction severity: Major — avoid combination

How Sacubitril Valsartan interacts with Valsartan

Sacubitril-valsartan already contains valsartan, so additional valsartan duplicates angiotensin receptor blockade and increases hypotension, renal impairment, and hyperkalaemia risk.

What you should do

Do not co-prescribe; discontinue separate valsartan when initiating sacubitril-valsartan.

Key facts

Severity

Major — avoid combination

Mechanism

Sacubitril-valsartan already contains valsartan, so additional valsartan duplicates angiotensin receptor blockade and in...

Action

Do not co-prescribe; discontinue separate valsartan when initiating sacubitril-valsartan.

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Sacubitril Valsartan and Valsartan together?

No — this combination should generally be avoided. Do not co-prescribe; discontinue separate valsartan when initiating sacubitril-valsartan.

What is the severity of this interaction?

The interaction between Sacubitril Valsartan and Valsartan is classified as Major — avoid combination. Sacubitril-valsartan already contains valsartan, so additional valsartan duplicates angiotensin receptor blockade and increases hypotension, renal impairment, and hyperkalaemia risk.

What should I do if I'm prescribed both?

Do not co-prescribe; discontinue separate valsartan when initiating sacubitril-valsartan. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.