Linezolid and Pseudoephedrine: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Linezolid and Pseudoephedrine unless specifically directed by your doctor.
How Linezolid interacts with Pseudoephedrine
Linezolid is a reversible MAO inhibitor; co-administration with sympathomimetic pseudoephedrine can precipitate hypertensive crisis.
What you should do
Avoid combination. Counsel patients to avoid OTC decongestants during linezolid therapy and for 2 weeks after discontinuation.
Key facts
Severity
Major — avoid combination
Mechanism
Linezolid is a reversible MAO inhibitor; co-administration with sympathomimetic pseudoephedrine can precipitate hyperten...
Action
Avoid combination. Counsel patients to avoid OTC decongestants during linezolid therapy and for 2 weeks after discontinu...
Frequently asked questions
Can I take Linezolid and Pseudoephedrine together?
No — this combination should generally be avoided. Avoid combination. Counsel patients to avoid OTC decongestants during linezolid therapy and for 2 weeks after discontinuation.
What is the severity of this interaction?
The interaction between Linezolid and Pseudoephedrine is classified as Major — avoid combination. Linezolid is a reversible MAO inhibitor; co-administration with sympathomimetic pseudoephedrine can precipitate hypertensive crisis.
What should I do if I'm prescribed both?
Avoid combination. Counsel patients to avoid OTC decongestants during linezolid therapy and for 2 weeks after discontinuation. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.