Monoamine Oxidase Inhibitors and Pseudoephedrine: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Monoamine Oxidase Inhibitors and Pseudoephedrine unless specifically directed by your doctor.
How Monoamine Oxidase Inhibitors interacts with Pseudoephedrine
Monoamine oxidase inhibitors reduce catecholamine breakdown, while pseudoephedrine increases adrenergic stimulation. The combination can cause severe hypertension or hypertensive crisis.
What you should do
Contraindicate concurrent use and avoid pseudoephedrine for at least 14 days after stopping most MAO inhibitors. Use non-adrenergic alternatives for nasal congestion.
Key facts
Severity
Major — avoid combination
Mechanism
Monoamine oxidase inhibitors reduce catecholamine breakdown, while pseudoephedrine increases adrenergic stimulation. The...
Action
Contraindicate concurrent use and avoid pseudoephedrine for at least 14 days after stopping most MAO inhibitors. Use non...
Frequently asked questions
Can I take Monoamine Oxidase Inhibitors and Pseudoephedrine together?
No — this combination should generally be avoided. Contraindicate concurrent use and avoid pseudoephedrine for at least 14 days after stopping most MAO inhibitors. Use non-adrenergic alternatives for nasal congestion.
What is the severity of this interaction?
The interaction between Monoamine Oxidase Inhibitors and Pseudoephedrine is classified as Major — avoid combination. Monoamine oxidase inhibitors reduce catecholamine breakdown, while pseudoephedrine increases adrenergic stimulation. The combination can cause severe hypertension or hypertensive crisis.
What should I do if I'm prescribed both?
Contraindicate concurrent use and avoid pseudoephedrine for at least 14 days after stopping most MAO inhibitors. Use non-adrenergic alternatives for nasal congestion. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.