Linezolid and Mirtazapine: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Linezolid and Mirtazapine unless specifically directed by your doctor.
How Linezolid interacts with Mirtazapine
Linezolid's MAO-A inhibition combined with mirtazapine's serotonergic activity can precipitate serotonin syndrome with hyperthermia, autonomic instability and clonus.
What you should do
Avoid co-administration; if linezolid is essential, withhold mirtazapine and monitor for 24 hours after the last dose before starting linezolid.
Key facts
Severity
Major — avoid combination
Mechanism
Linezolid's MAO-A inhibition combined with mirtazapine's serotonergic activity can precipitate serotonin syndrome with h...
Action
Avoid co-administration; if linezolid is essential, withhold mirtazapine and monitor for 24 hours after the last dose be...
Frequently asked questions
Can I take Linezolid and Mirtazapine together?
No — this combination should generally be avoided. Avoid co-administration; if linezolid is essential, withhold mirtazapine and monitor for 24 hours after the last dose before starting linezolid.
What is the severity of this interaction?
The interaction between Linezolid and Mirtazapine is classified as Major — avoid combination. Linezolid's MAO-A inhibition combined with mirtazapine's serotonergic activity can precipitate serotonin syndrome with hyperthermia, autonomic instability and clonus.
What should I do if I'm prescribed both?
Avoid co-administration; if linezolid is essential, withhold mirtazapine and monitor for 24 hours after the last dose before starting linezolid. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.