Mirtazapine and Phenelzine: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Mirtazapine and Phenelzine unless specifically directed by your doctor.

Interaction severity: Major — avoid combination

How Mirtazapine interacts with Phenelzine

Phenelzine irreversibly inhibits monoamine oxidase, while mirtazapine enhances noradrenergic and serotonergic neurotransmission. The combination can precipitate serotonin toxicity or hypertensive reactions.

What you should do

Do not coadminister. Use appropriate washout periods when switching between these medicines.

Key facts

Severity

Major — avoid combination

Mechanism

Phenelzine irreversibly inhibits monoamine oxidase, while mirtazapine enhances noradrenergic and serotonergic neurotrans...

Action

Do not coadminister. Use appropriate washout periods when switching between these medicines.

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Mirtazapine and Phenelzine together?

No — this combination should generally be avoided. Do not coadminister. Use appropriate washout periods when switching between these medicines.

What is the severity of this interaction?

The interaction between Mirtazapine and Phenelzine is classified as Major — avoid combination. Phenelzine irreversibly inhibits monoamine oxidase, while mirtazapine enhances noradrenergic and serotonergic neurotransmission. The combination can precipitate serotonin toxicity or hypertensive reactions.

What should I do if I'm prescribed both?

Do not coadminister. Use appropriate washout periods when switching between these medicines. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.