Itraconazole and Palbociclib: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Itraconazole and Palbociclib unless specifically directed by your doctor.
How Itraconazole interacts with Palbociclib
Itraconazole strongly inhibits CYP3A4, the principal metabolic pathway for palbociclib, increasing exposure and the risk of severe neutropenia and other toxicity.
What you should do
Avoid strong CYP3A4 inhibitors during palbociclib treatment. If unavoidable, apply the product-specific palbociclib dose reduction and monitor blood counts closely.
Key facts
Severity
Major — avoid combination
Mechanism
Itraconazole strongly inhibits CYP3A4, the principal metabolic pathway for palbociclib, increasing exposure and the risk...
Action
Avoid strong CYP3A4 inhibitors during palbociclib treatment. If unavoidable, apply the product-specific palbociclib dose...
Frequently asked questions
Can I take Itraconazole and Palbociclib together?
No — this combination should generally be avoided. Avoid strong CYP3A4 inhibitors during palbociclib treatment. If unavoidable, apply the product-specific palbociclib dose reduction and monitor blood counts closely.
What is the severity of this interaction?
The interaction between Itraconazole and Palbociclib is classified as Major — avoid combination. Itraconazole strongly inhibits CYP3A4, the principal metabolic pathway for palbociclib, increasing exposure and the risk of severe neutropenia and other toxicity.
What should I do if I'm prescribed both?
Avoid strong CYP3A4 inhibitors during palbociclib treatment. If unavoidable, apply the product-specific palbociclib dose reduction and monitor blood counts closely. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.