Palbociclib and Posaconazole: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Palbociclib and Posaconazole unless specifically directed by your doctor.
How Palbociclib interacts with Posaconazole
Posaconazole strongly inhibits CYP3A4, the principal pathway for palbociclib metabolism, substantially increasing palbociclib exposure and myelosuppression risk.
What you should do
Avoid coadministration and select a non-strong CYP3A4 inhibitor. If unavoidable, use the product-specific reduced palbociclib dose and monitor blood counts closely.
Key facts
Severity
Major — avoid combination
Mechanism
Posaconazole strongly inhibits CYP3A4, the principal pathway for palbociclib metabolism, substantially increasing palboc...
Action
Avoid coadministration and select a non-strong CYP3A4 inhibitor. If unavoidable, use the product-specific reduced palboc...
Frequently asked questions
Can I take Palbociclib and Posaconazole together?
No — this combination should generally be avoided. Avoid coadministration and select a non-strong CYP3A4 inhibitor. If unavoidable, use the product-specific reduced palbociclib dose and monitor blood counts closely.
What is the severity of this interaction?
The interaction between Palbociclib and Posaconazole is classified as Major — avoid combination. Posaconazole strongly inhibits CYP3A4, the principal pathway for palbociclib metabolism, substantially increasing palbociclib exposure and myelosuppression risk.
What should I do if I'm prescribed both?
Avoid coadministration and select a non-strong CYP3A4 inhibitor. If unavoidable, use the product-specific reduced palbociclib dose and monitor blood counts closely. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.