Ethinylestradiol and Oxcarbazepine: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Ethinylestradiol and Oxcarbazepine unless specifically directed by your doctor.
How Ethinylestradiol interacts with Oxcarbazepine
Oxcarbazepine induces CYP3A4 and glucuronidation pathways, lowering ethinylestradiol exposure and increasing the risk of contraceptive failure.
What you should do
Do not rely on an ethinylestradiol-containing contraceptive as the sole method. Use a contraceptive unaffected by enzyme induction, preferably an intrauterine method.
Key facts
Severity
Major — avoid combination
Mechanism
Oxcarbazepine induces CYP3A4 and glucuronidation pathways, lowering ethinylestradiol exposure and increasing the risk of...
Action
Do not rely on an ethinylestradiol-containing contraceptive as the sole method. Use a contraceptive unaffected by enzyme...
Frequently asked questions
Can I take Ethinylestradiol and Oxcarbazepine together?
No — this combination should generally be avoided. Do not rely on an ethinylestradiol-containing contraceptive as the sole method. Use a contraceptive unaffected by enzyme induction, preferably an intrauterine method.
What is the severity of this interaction?
The interaction between Ethinylestradiol and Oxcarbazepine is classified as Major — avoid combination. Oxcarbazepine induces CYP3A4 and glucuronidation pathways, lowering ethinylestradiol exposure and increasing the risk of contraceptive failure.
What should I do if I'm prescribed both?
Do not rely on an ethinylestradiol-containing contraceptive as the sole method. Use a contraceptive unaffected by enzyme induction, preferably an intrauterine method. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.