Enalapril and Sacubitril: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Enalapril and Sacubitril unless specifically directed by your doctor.

Interaction severity: Major — avoid combination

How Enalapril interacts with Sacubitril

Simultaneous ACE and neprilysin inhibition increases bradykinin accumulation and substantially raises the risk of angioedema.

What you should do

Do not administer concurrently. Allow a washout period of at least 36 hours between enalapril and a sacubitril-containing medicine.

Key facts

Severity

Major — avoid combination

Mechanism

Simultaneous ACE and neprilysin inhibition increases bradykinin accumulation and substantially raises the risk of angioe...

Action

Do not administer concurrently. Allow a washout period of at least 36 hours between enalapril and a sacubitril-containin...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Enalapril and Sacubitril together?

No — this combination should generally be avoided. Do not administer concurrently. Allow a washout period of at least 36 hours between enalapril and a sacubitril-containing medicine.

What is the severity of this interaction?

The interaction between Enalapril and Sacubitril is classified as Major — avoid combination. Simultaneous ACE and neprilysin inhibition increases bradykinin accumulation and substantially raises the risk of angioedema.

What should I do if I'm prescribed both?

Do not administer concurrently. Allow a washout period of at least 36 hours between enalapril and a sacubitril-containing medicine. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.