Dexamethasone and Rilpivirine: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Dexamethasone and Rilpivirine unless specifically directed by your doctor.
How Dexamethasone interacts with Rilpivirine
Systemic dexamethasone induces CYP3A4, which can reduce rilpivirine concentrations and compromise antiviral efficacy.
What you should do
Avoid systemic dexamethasone except possibly a single dose. Choose an alternative corticosteroid or antiretroviral regimen.
Key facts
Severity
Major — avoid combination
Mechanism
Systemic dexamethasone induces CYP3A4, which can reduce rilpivirine concentrations and compromise antiviral efficacy.
Action
Avoid systemic dexamethasone except possibly a single dose. Choose an alternative corticosteroid or antiretroviral regim...
Frequently asked questions
Can I take Dexamethasone and Rilpivirine together?
No — this combination should generally be avoided. Avoid systemic dexamethasone except possibly a single dose. Choose an alternative corticosteroid or antiretroviral regimen.
What is the severity of this interaction?
The interaction between Dexamethasone and Rilpivirine is classified as Major — avoid combination. Systemic dexamethasone induces CYP3A4, which can reduce rilpivirine concentrations and compromise antiviral efficacy.
What should I do if I'm prescribed both?
Avoid systemic dexamethasone except possibly a single dose. Choose an alternative corticosteroid or antiretroviral regimen. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.