Pantoprazole and Rilpivirine: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Pantoprazole and Rilpivirine unless specifically directed by your doctor.
How Pantoprazole interacts with Rilpivirine
Proton pump inhibitors markedly increase gastric pH, reducing rilpivirine solubility and absorption. Subtherapeutic rilpivirine exposure can lead to virologic failure and resistance.
What you should do
Do not coadminister rilpivirine with proton pump inhibitors. Use an alternative antiretroviral regimen or acid-suppression strategy consistent with HIV treatment guidance.
Key facts
Severity
Major — avoid combination
Mechanism
Proton pump inhibitors markedly increase gastric pH, reducing rilpivirine solubility and absorption. Subtherapeutic rilp...
Action
Do not coadminister rilpivirine with proton pump inhibitors. Use an alternative antiretroviral regimen or acid-suppressi...
Frequently asked questions
Can I take Pantoprazole and Rilpivirine together?
No — this combination should generally be avoided. Do not coadminister rilpivirine with proton pump inhibitors. Use an alternative antiretroviral regimen or acid-suppression strategy consistent with HIV treatment guidance.
What is the severity of this interaction?
The interaction between Pantoprazole and Rilpivirine is classified as Major — avoid combination. Proton pump inhibitors markedly increase gastric pH, reducing rilpivirine solubility and absorption. Subtherapeutic rilpivirine exposure can lead to virologic failure and resistance.
What should I do if I'm prescribed both?
Do not coadminister rilpivirine with proton pump inhibitors. Use an alternative antiretroviral regimen or acid-suppression strategy consistent with HIV treatment guidance. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.