Ritonavir and Tacrolimus: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Ritonavir and Tacrolimus unless specifically directed by your doctor.
How Ritonavir interacts with Tacrolimus
Ritonavir is a potent CYP3A4 and P-glycoprotein inhibitor, causing large increases in tacrolimus exposure and nephrotoxicity risk.
What you should do
Avoid or manage only with specialist input. Hold or drastically reduce tacrolimus and monitor trough concentrations and renal function closely.
Key facts
Severity
Major — avoid combination
Mechanism
Ritonavir is a potent CYP3A4 and P-glycoprotein inhibitor, causing large increases in tacrolimus exposure and nephrotoxi...
Action
Avoid or manage only with specialist input. Hold or drastically reduce tacrolimus and monitor trough concentrations and ...
Frequently asked questions
Can I take Ritonavir and Tacrolimus together?
No — this combination should generally be avoided. Avoid or manage only with specialist input. Hold or drastically reduce tacrolimus and monitor trough concentrations and renal function closely.
What is the severity of this interaction?
The interaction between Ritonavir and Tacrolimus is classified as Major — avoid combination. Ritonavir is a potent CYP3A4 and P-glycoprotein inhibitor, causing large increases in tacrolimus exposure and nephrotoxicity risk.
What should I do if I'm prescribed both?
Avoid or manage only with specialist input. Hold or drastically reduce tacrolimus and monitor trough concentrations and renal function closely. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.