Cyclosporine and Hypericum Perforatum: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Cyclosporine and Hypericum Perforatum unless specifically directed by your doctor.
How Cyclosporine interacts with Hypericum Perforatum
Hypericum perforatum induces CYP3A4 and P-glycoprotein, markedly reducing cyclosporine concentrations and risking transplant rejection.
What you should do
Do not combine. If Hypericum perforatum has been taken, stop it under clinical supervision and monitor cyclosporine concentrations closely because induction resolves gradually.
Key facts
Severity
Major — avoid combination
Mechanism
Hypericum perforatum induces CYP3A4 and P-glycoprotein, markedly reducing cyclosporine concentrations and risking transp...
Action
Do not combine. If Hypericum perforatum has been taken, stop it under clinical supervision and monitor cyclosporine conc...
Frequently asked questions
Can I take Cyclosporine and Hypericum Perforatum together?
No — this combination should generally be avoided. Do not combine. If Hypericum perforatum has been taken, stop it under clinical supervision and monitor cyclosporine concentrations closely because induction resolves gradually.
What is the severity of this interaction?
The interaction between Cyclosporine and Hypericum Perforatum is classified as Major — avoid combination. Hypericum perforatum induces CYP3A4 and P-glycoprotein, markedly reducing cyclosporine concentrations and risking transplant rejection.
What should I do if I'm prescribed both?
Do not combine. If Hypericum perforatum has been taken, stop it under clinical supervision and monitor cyclosporine concentrations closely because induction resolves gradually. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.